Ferulago pauciradiata Boiss. & Heldr. Effects of Prantschimgin Compound Isolated from the Root of the Plant on LPS-Induced Inflammation Model in the L929 Cell Line

Investigation of the effects prantchimgin (Prn) compound isolated from root part Ferulago pauciradiata (Apiaceae) plant in lipopolysaccharide (LPS) cytotoxicity model created L929 cell line. lines were applied a 5% CO2 incubator at 37 °C, using standard culture procedures, LPS was with Prn pure substance final concentration 2 µL and 1 after hour. Following application, MTT protocol, colorimetric method, to determine viability end required 24th, 48th, 72nd hours incubation times. IC50 values calculated as 0.28 µg/mL for Pnr LPS. Application caused significant decrease cellular index depending on time. Also, + groups, it found that decreased significantly increased even closer control compared group. It cyctoxicity damage by line improved application.